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Role of lubricin and boundary lubrication in the

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Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis | SpringerLi

Osteoarthritis (OA) is a multi-factor disorder of sinovial joints, which characterized by escalated degeneration and loss of articular cartilage. Treatment of OA is a critical unmet ...

The role of lubricin in the mechanical behavior of synovial flui

The role of lubricin in the mechanical behavior of synovial fluid. Jay GD(1), Torres JR, Warman ML, ... where it contributes to boundary lubrication under load. Individuals with genetic deficiency of lubricin develop precocious joint failure. The role of lubricin in We ...

The role of lubricin in normal and pathological joint tissue: a contemporary revi

boundary lubrication of congruent articular surfaces under conditions of high contact pressure and near-zero sliding speed. ... The role of lubricin in normal and pathological joint tissue: a contemporary review. OA Anatomy 2013 Feb 01;1(1):2. rod and, in solution ...

Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament .

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Transcription, Translation, and Function of Lubricin, a Boundary Lubricant, at the Ocular Surface | Cornea | JAMA Ophthalmology | JAMA Netwo

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic ... responsible for boundary mode lubrication at the ocular surface supports the hypothesis of Ehlers, 28 who theorized that boundary lubrication must take place 29 28 ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients ...

Proteoglycan 4 - Wikiped

Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin ...

Supramolecular synergy in the boundary lubrication of synovial joints | Nature Communicatio

with a very different role, to provide the boundary lubrication characteristic of healthy synovial joints: ... The role of lubricin in the mechanical behavior of synovial fluid. Proc. Natl Acad. Sci. USA 104, 6194–6199 (2007) . CAS PubMed Article 33. Linn, F . ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Kimberly A Waller | Request P

Request PDF on ResearchGate | Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and ...

Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approach

Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | PN

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication | SpringerLi

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication Authors Authors and affiliations ...

The role of lubricin in normal and pathological joint tissue: A contemporary review.OA Anato

The role of lubricin in normal and pathological joint tissue: a contemporary review G Musumeci 1* Authors affiliations (1) ... It has been shown that lubricin is critical to normal joint function, providing boundary lubrication of congruent articular surfaces under ...

Stimulation of Superficial Zone Protein/Lubricin/PRG4 by Transforming Growth Factor-β in Superficial Zone Articular Chondrocytes and Modulation .

Superficial zone protein (SZP), also known as lubricin and proteoglycan 4 (PRG4), plays an important role in the boundary lubrication of articular cartilage and is regulated by transforming growth factor (TGF)-β. Here, we evaluate the role of cell surface ...

The role of lubricin in the mechanical behavior of synovial fluid. | Sigma-Aldri

Abstract Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under ...

The role of lubricin in the mechanical behavior of synovial fluid | G D Jay | Request P

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA–protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfac

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfaces ... a mixture the two to further understand the role of lubricin in boundary lubrication and to examine the hypotheses that lubri-cin and HA, alone or in ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the ...