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Disulfiram when Combined with Copper Enhances the

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Lun X, Wells JC, Grinshtein N, et al. Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma. Clin Cancer Res. 2016; 22:3860–75. [PubMed: 27006494] 8. Pantziarka P, Bouche G, Meheus L ...

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma. | Docph

PubMedID: 27006494 | Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma. | Clinical Cancer Research | 8/1/2016 Sign Up Remember Me Can't access your account? ...

Disulfiram/copper causes redox-related proteotoxicity and concomitant heat shock response in ovarian cancer cells that is augmented by auranofin .

In preclinical studies, disulfiram, when combined with copper ions, has been shown to act as a proteasome inhibitor, to induce oxidative stress, reduce NFkB activity, and enhance the sensitivity of cancer cells to chemotherapeutic drugs []. ...

A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma | SpringerLi

Uehling D, Datti A, Wrana JL, Easaw JC, Luchman A, Weiss S, Cairncross JG, Kaplan DR, Robbins SM, Senger DL (2016) Disulfiram when combined with copper enhances the therapeutic effects of temozolomide for the treatment of glioblastoma. Clin ...

disulfiram (DSF) - Allie: Related PubMed Inf

Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-kappaB and TGF-beta pathways. EMT, HCC 17 2018 Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion , ...

Papers with the keyword disulfiram copper (Page 3) | Read by Qx

Read papers from the keyword disulfiram copper with Read by QxMD. keyword — MENU Read CLOSE Read Login Featured Journals Collections Favorites papers topics Sign In Create Account × Want to receive updates for this keyword? Use Read by ...

(PDF) Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblasto

PDF | Purpose: Glioblastoma is one of the most lethal cancers in humans, and with existing therapy, survival remains at 14.6 months. Current barriers to successful treatment include their infiltrative behavior, extensive tumor heterogeneity, and the presence of a ...

Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitors - ScienceDire

Disulfiram (DSF) in combination with copper (Cu) has been reported to override drug resistance in cancer cells, and DSF combined with chemotherapy based on the microtubule inhibitor vinorelbine appears to prolong survival in non-small cell lung cancer patients.

Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitors - ScienceDire

Disulfiram (DSF) in combination with copper (Cu) has been reported to override drug resistance in cancer cells, and DSF combined with chemotherapy based on the microtubule inhibitor vinorelbine appears to prolong survival in non-small cell lung cancer patients.

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma | Clinical Cancer Resear

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma Xueqing Lun, J. Connor Wells, Natalie Grinshtein, Jennifer C. King, ...

Combination Therapy with Disulfiram, Copper, and Doxorubicin for Osteosarcoma: In Vitro Support for a Novel Drug Repurposing Strate

Copper transporters were quantified by qPCR. Cytotoxicity of doxorubicin, disulfiram, and copper(II) chloride was assessed with a cell viability fluorescence stain. Additionally, K7M2 viable cell counts were determined by trypan blue exclusion staining after 72&# ...

Disulfiram repurposing combined with nutritional... | F1000Resear

Jakola AS, Werlenius K, Mudaisi M et al. Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial [version 1; peer review: 2 approved]. ...

our brain tumor cocktails and stories: Disulfiram when combined with copper enhances the therapeutic effects of temozolomide for the treatment of .

Great article Stephen. The dose of 2 mg/kg copper was used. what is the human equivalent? Looks like they gave the disulfiram copper TMZ combination at the same time. I wonder if this is best or if taking the disulfiram /copper combination at a different time ...

Disulfiram when combined with copper enhances the therapeutic effects of temozolomide for the treatment of glioblastoma | IRIS Università degli .

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Disulfiram when Combined with Copper Enhances the Therapeutic... - Cite

Products referenced in Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma. ... Abstract Glioblastoma is one of the most lethal cancers in humans, and with existing therapy, survival remains ...

Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells | British Journal of Canc

Disulfiram/copper enhances the cytotoxicity of dFdC. Combination index-isobologram analysis indicates a synergistic effect between DS/Cu and dFdC. Disulfiram/copper induces reactive oxygen species (ROS), ...

The Role of Copper in Disulfiram-Induced Toxicity and Radiosensitization of Cancer Cel

Furthermore, the enhanced clonogenic kill induced by combined disulfiram and radiation treatment relative to single-agent treatment was prevented by serum removal (P < 0.05) or addition of BCPD (P < 0.05). In contrast, incubation with copper resulted in ...

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastom

Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. ... View This Abstract Online Disulfiram when Combined with Copper Enhances the Therapeutic Effects of ...

Inhibitory effect of Disulfiram/copper complex on non-small cell lung cancer cells - ScienceDire

Disulfiram combined with copper significantly attenuated NSCLC cell spheroid formation and recuded the mRNA expression of lung cancer stem cell related genes. ...

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma | Clinical Cancer Resear

Purpose: Glioblastoma is one of the most lethal cancers in humans, and with existing therapy, survival remains at 14.6 months. Current barriers to successful treatment include their infiltrative behavior, extensive tumor heterogeneity, and the presence of a stem-like ...